The Generally Recognized Safety of Dimethyl Sulfoxide (DMSO) in Human-Use Medical Applications

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Dimethyl Sulfoxide (DMSO) is FDA approved as the active ingredient in Mylan’s “RIMSO-50”:

https://www.hipaaspace.com/medical_billing/coding/national.drug.codes/67457-177-50

The FDA has approved DMSO as an inactive ingredient for intravenous, subcutaneous, and topical (both lotion and solution) delivery routes. Search the FDA’s inactive ingredient database for Dimethyl Sulfoxide here:

https://www.accessdata.fda.gov/scripts/cder/iig/index.cfm

PENNSAID is one example of an FDA approved topical drug-using DMSO to increase transdermal absorption:

https://www.pennsaid.com/targeted-oa-knee-pain-relief

For use in these FDA approved applications, the Gaylord Chemical Company produces high purity DMSO under the trade name “Procipient” in their FDA-inspected facility:

https://www.gaylordchemical.com/products/product-grades/procipient/

From that page:

“DMSO is essentially non-toxic by all routes of administration. It is well tolerated by oral and dermal route of delivery as well as subcutaneous and intramuscular delivery.”

DMSO is also FDA approved for use in horses and dogs, and Zoetis produces it under the trade name “Domoso”:

https://www.drugs.com/vet/domoso-solution.html

For further reading:

  1. https://www.rxlist.com/dmso_dimethylsulfoxide/supplements.htm
  2. https://pubmed.ncbi.nlm.nih.gov/22030943/
  3. https://www.pharmtech.com/view/advances-regulated-pharmaceutical-use-dimethyl-sulfoxide-usp-pheur

There are a large number of books that advocate human use of DMSO:

  1. Dimethyl Sulfoxide (DMSO) in Trauma and Disease by Stanley W. Jacob
  2. The DMSO Handbook: A New Paradigm in Healthcare by Dr Hartmut Fischer
  3. DMSO Handbook: A Complete Guide to the History and Use of DMSO by Bruce Halstead
  4. The DMSO Handbook for Doctors by Archie H. Scott
  5. DMSO: Nature’s Healer by Morton Walker
  6. DMSO: THE UNIVERSAL HEALER by Dr. Kendra Nathan
  7. THE HEALING WONDERS OF DMSO by Dr. Marylyn G. Andrea 
  8. HEALING PROPERTIES OF DMSO by Eric Goldinger
  9. NATURAL REMEDY DMSO: A MIRACLE DRUG by Lata Dorella
  10. DMSO Treatments by Thomas Henry
  11. EVERYTHING YOU NEED TO KNOW ABOUT DMSO by Matilda Sean
  12. DMSO: Nature’s Universal Healer by Dr. Patricia W. Alex
  13. DMSO: THE UNIVERSAL HEALING WONDER by Dr. Steven Carson
  14. BEGINNERS GUIDE TO HEALING WITH DMSO by Lisa H. Gregory Ph.D
  15. DMSO: The True Story of a Remarkable Pain Killing Drug by Barry Tarshis
  16. DMSO: Responsible User’s Guide by Thomas Bristol
  17. Benefits Of Drinking DMSO by Rudolf Spara
  18. Optimal Healing with DMSO by Wendy Sullivan MD
  19. Persecuted Drug: The Story of DMSO by Pat McGrady
  20. DMSO: The Unique All-Time Healer by Dr. Isaac Joe
  21. New Method Of Healing With DMSO by Williams Evelyn
  22. Holistic Healing with DMSO by Dr. Elizabeth David
  23. Healing with DMSO by Dr. Tracy Brian
  24. Simplified Guide To Healing With DMSO by Enedino Smith

These companies produce DMSO nominally as a solvent for legal/regulatory reasons, but commonly used for human medical purposes:

  1. Jacob Laboratories: https://www.jacoblab.com/
  2. Nature’s Gift: https://naturesgift-dmso.com/
  3. DMSO Store: https://dmsostore.com/
  4. Biogenic Foods: https://biogenicfoods.com/dmso-dimethyl-sulfoxide-pharmaceutical-grade-99-999-pure-undiluted-usa-produced/
  5. Heiltropfen: https://www.heiltropfen.de/shop/en/21-dmso